Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction
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چکیده
منابع مشابه
Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction.
Brain microvascular endothelial cells (BMVEC) connected by tight junctions (TJ) form a tight monolayer at the blood-brain barrier (BBB). We investigated the idea that BBB dysfunction seen in alcohol abuse is associated with oxidative stress stemming from ethanol (EtOH) metabolism in BMVEC. Exposure to EtOH induced catalytic activity/expression of EtOH-metabolizing enzymes, which paralleled enha...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2005
ISSN: 0741-5400
DOI: 10.1189/jlb.0605340